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整合素αVβ3抗體

產(chǎn)品貨號：

BN42193R
中文名稱：

整合素αVβ3抗體
英文名稱：

Rabbit anti-Integrin Alpha V + Beta 3 (CD51+CD61) Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42193R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN42193R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN42193R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	Integrin Alpha V + Beta 3 (CD51+CD61)
中文名稱	整合素αVβ3抗體
別名	CD51 + CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v beta 3; ITGAV; ITGB3; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; VNRA; Antigen identified by monoclonal antibody L230; CD51 antigen; CD61 antigen; DKFZp686A08142; Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin alpha v; Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin beta chain beta 3; intregrin alpha v beta 3; ITGAV; MSK8; Platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha; avb3.

研究領域	細胞生物免疫學信號轉(zhuǎn)導干細胞細胞粘附分子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat,
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. Subcellular Location: Cell Membrane; single-pass type I membrane protein. SWISS: P05106, P06756 Gene ID: 3685 Database links: Entrez Gene: 3685 Human Entrez Gene: 3690 Human Omim: 173470 Human Omim: 193210 Human SwissProt: P05106 Human SwissProt: P06756 Human Unigene: 218040 Human Unigene: 436873 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 整合素αVβ3為二聚體的跨膜糖蛋白質(zhì)，可以調(diào)節(jié)腫瘤細胞在多種細胞外基質(zhì)蛋白中的粘附和遷移，在被激活的內(nèi)皮細胞中有較高的表達，并在新生血管生成過程中發(fā)揮優(yōu)勢。整合素αVβ3在細胞外的信號傳入細胞內(nèi)調(diào)節(jié)細胞生長、改變細胞形態(tài)、影響細胞運動, 并在腫瘤侵襲和轉(zhuǎn)移的過程中起重要作用.整合素αVβ3是特異性表達在血管內(nèi)皮細胞表面的粘附因子。