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產(chǎn)品規(guī)格
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BN41268R-100ul
100ul
￥2360.00
交叉反應：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41268R-200ul
200ul
￥3490.00
交叉反應：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | SMC6 |
| 中文名稱 | 染色體結(jié)構(gòu)維持蛋白6抗體 |
| 別 名 | SMC6L1; SMC 6; SMC6; SMC6 protein; SMC6 structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes protein 6. |
| 研究領(lǐng)域 | 細胞生物 細胞周期蛋白 細胞分化 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 126 kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SMC6:155-260/1091 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Subunit: Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed. Overexpressed in testis. Post-translational modifications: Ubiquitinated. Similarity: Belongs to the SMC family. SMC6 subfamily. SWISS: Q96SB8 Gene ID: 79677 Database links: UniProtKB/Swiss-Prot: Q96SB8.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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